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RENOVITE®, a synthetic nanoclay for precision therapeutics delivery

RENOVITE®, a synthetic nanoclay gel scaffold for effective localised therapeutics delivery

Renovos is pioneering synthetic nanoclays for medical applications

For decades, clays have been used in tablets to control drug release through their molecule binding properties. For instance, these binding properties ensure that molecules stay localised. Renovos has developed an innovative solution to molecule diffusion based on synthetic nanoclay, RENOVITE®. RENOVITE® provides a localised environment conductive to cell infiltration, whilst retaining bioactive molecules, until it is gradually replaced with newly regenerated tissue, acting as a precise template.

RENOVITE® BMP-2 – our nanoclay based orthobiologic

Clinical use of the BMP-2 protein for spine fusion has severe safety and handling limitations. To overcome these, we have developed RENOVITE® BMP-2, an injectable carrier based on synthetic nanoclay that binds and delivers BMP-2 to allow precise templating of new bone formation, and therefore safer and more efficient bone fusion.

RENOVITE® BMP-2 offers:

High-precision handling

RENOVITE® BMP-2 is injectable and can pass through a 23G needle

Retention at target site

Two photos of RENOVITE-BMP2 gel set in cage under a water spray, showcasing the ability of the material to resist pressure. Next to the photos, a graph showing that retention of RENOVITE-BMP2 outperforms a clinical product.

RENOVITE BMP-2 remains where injected and retains BMP-2 at site whilst new bone forms

Improved bone fusion quality

RENOVITE BMP-2 leads to higher quality of regenerated bone, avoiding the common “eggshell effect” 

Key advantages of RENOVITE® nanoclay technology:

Improved safety

reduced non-specific effects

Easy to use

injectable and suitable for minimally-invasive procedures

Improved efficacy

sustained localised retention, leading to higher bioavailability

Customisable

able to deliver a broad variety of molecules

Reduced costs

reduced biologic doses and reduced need for revision procedures

Biocompatible and resorbable

gradually replaced with newly regenerated tissue